ALZFORUM | NETWORKING FOR A CURE
5 days ago · Jason Ulrich and David Holtzman on APOE from astrocytes restores Alzheimer's Aβ-pathology and DAM-like responses in APOE deficient microglia. 20 Dec 2024; Sarah Heuer on APOE from astrocytes restores Alzheimer's Aβ-pathology and DAM-like responses in APOE deficient microglia. 20 Dec 2024; Taisuke Tomita on Sans Presenilin-2, Lysosomes Struggle. Synapses, Memory Circuits Erode 20 Dec 2024
Leqembi - ALZFORUM
Overview. Name: Leqembi Synonyms: Lecanemab-irmb, BAN2401, mAb158 Therapy Type: Immunotherapy (passive) Target Type: Amyloid-Related Condition(s): Alzheimer's Disease U.S. FDA Status: Alzheimer's Disease (Approved) Company: BioArctic AB, Biogen, Eisai Co., Ltd. Background. BAN2401 is the humanized IgG1 version of the mouse monoclonal antibody mAb158, which selectively binds to large, soluble ...
Databases - ALZFORUM
AlzAntibodies. This database aims to provide detailed descriptions of selected antibodies related to the study of Alzheimer’s disease. AlzBiomarker
AL101 | ALZFORUM
Jul 10, 2024 · Overview. Name: AL101 Synonyms: GSK-4527226 Therapy Type: Immunotherapy (passive) Target Type: Other Condition(s): Alzheimer's Disease U.S. FDA Status: Alzheimer's Disease (Phase 2) Company: Alector, GlaxoSmithKline (GSK) Background. AL101 is a monoclonal antibody to sortilin (SORT1), a trans-Golgi sorting receptor abundantly expressed in the nervous system.
Trontinemab - ALZFORUM
May 9, 2024 · Overview. Name: Trontinemab Synonyms: RO7126209, RG6102 , Brain shuttle gantenerumab Therapy Type: Immunotherapy (passive) Target Type: Amyloid-Related Condition(s): Alzheimer's Disease U.S. FDA Status: Alzheimer's Disease (Phase 1/2) Company: Hoffmann-La Roche Background. RO7126209 is a new version of the anti-amyloid monoclonal antibody gantenerumab, engineered to more easily cross the blood ...
Remternetug - ALZFORUM
Overview. Name: Remternetug Synonyms: LY3372993, N3pG-Abeta mAb Therapy Type: Immunotherapy (passive) Target Type: Amyloid-Related Condition(s): Alzheimer's Disease U.S. FDA Status: Alzheimer's Disease (Phase 3) Company: Eli Lilly & Co. Background. Remternetug, previously LY3372993, is an investigational monoclonal antibody. Lilly's development pipeline lists it as an N3pG-Aβ mAb, suggesting ...
Bepranemab - ALZFORUM
Jan 23, 2022 · Overview. Name: Bepranemab Synonyms: UCB0107 , UCB 0107 , Antibody D Therapy Type: Immunotherapy (passive) Target Type: Tau Condition(s): Progressive Supranuclear Palsy, Alzheimer's Disease U.S. FDA Status: Progressive Supranuclear Palsy (Phase 1), Alzheimer's Disease (Phase 2) Company: Hoffmann-La Roche, UCB S.A. Background. This humanized, monoclonal IgG4 antibody binds to the central region ...
CT1812 | ALZFORUM
Nov 9, 2024 · Overview. Name: CT1812 Synonyms: Elayta Therapy Type: Small Molecule Target Type: Amyloid-Related Condition(s): Alzheimer's Disease U.S. FDA Status: Alzheimer's Disease (Phase 2) Company: Cognition Therapeutics Inc. Background. CT1812 is a small-molecule antagonist of the sigma2 receptor. The rationale behind this therapeutic approach is that ligands for the sigma2 receptor complex are ...
AL002 - ALZFORUM
Nov 25, 2024 · Overview. Name: AL002 Therapy Type: Immunotherapy (passive) Target Type: Inflammation Condition(s): Alzheimer's Disease U.S. FDA Status: Alzheimer's Disease (Discontinued) Company: AbbVie, Alector Background. This humanized monoclonal IgG1 antibody was being developed in a partnership between Alector and AbbVie. It binds the microglial receptor TREM2 and activates signaling, increasing ...
Simufilam | ALZFORUM
Apr 18, 2022 · Overview. Name: Simufilam Synonyms: PTI-125, sumifilam Chemical Name: 4-benzyl-8-methyl-1,4,8-triazaspiro[4.5]decan-3-one Therapy Type: Small Molecule Target Type: Amyloid-Related Condition(s): Alzheimer's Disease U.S. FDA Status: Alzheimer's Disease (Discontinued) Company: Cassava Sciences Background. Simufilam binds to filamin, a ubiquitous scaffolding protein and regulator of the actin ...
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