BACH1 - Wikipedia
Transcription regulator protein BACH1 is a protein that in humans is encoded by the BACH1 gene. [5][6][7] This gene encodes a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family (CNC-bZip).
BACH1 Gene - GeneCards | BACH1 Protein | BACH1 Antibody
Dec 24, 2024 · BACH1 (BTB Domain And CNC Homolog 1) is a Protein Coding gene. Diseases associated with BACH1 include Beta-Thalassemia and Breast Cancer. Among its related pathways are Nuclear events mediated by NFE2L2 and Cellular responses to stimuli.
Bach1: Function, Regulation, and Involvement in Disease
Oct 2, 2018 · The transcription factor BTB and CNC homology 1 (Bach1) is widely expressed in most mammalian tissues and functions primarily as a transcriptional suppressor by heterodimerizing with small Maf proteins and binding to Maf recognition elements in the promoters of targeted genes.
Transcription factor BACH1 in cancer: roles, mechanisms, and …
BACH1 has different functions in the regulation of apoptosis in the progression of cancer (Fig. 5). BACH1 is highly expressed in lung CSCs, where it increases the expression of BCL-2 protein and represses the expression of BAX as well as p53, thereby inhibiting apoptosis .
Bach1-dependent and -independent Regulation of Heme …
Bach1 Down-regulation Enhances HO-1 Expression but Does Not Reduce or Attenuate ROS Production. To investigate the function of Bach1 in the regulation of HO-1 in keratinocytes, we examined the levels of ROS in Bach1 −/− keratinocytes.
BACH1 Is a Specific Repressor of - PubMed Central (PMC)
Here, we investigate the effect of BACH1 inactivation on the induction of HMOX1 and as a mechanism for broader gene induction. We show that BACH1 is inactivated at low micromolar arsenite concentrations and that BACH1 inactivation is necessary and sufficient for transcriptional induction of HMOX1.
BACH1 changes microglial metabolism and affects astrogenesis …
Jan 8, 2024 · The transcription factor BTB and CNC homology 1 (Bach1) reduces lactate production by inhibiting two key enzymes, HK2 and GAPDH, during glycolysis. Metabolic perturbation of microglia reduces lactate-dependent histone modification enrichment at …
What are BACH1 inhibitors and how do they work? - Patsnap
Jun 25, 2024 · BACH1 inhibitors function by blocking the activity of the BACH1 protein, thereby preventing it from binding to DNA and repressing the transcription of target genes. This inhibition can be achieved through various mechanisms, including small molecules that directly interact with BACH1 or by interfering with its dimerization, which is essential ...
BACH1 controls hepatic insulin signaling and glucose ... - Nature
Dec 21, 2023 · Hepatocyte-specific Bach1 deletion in male mice on a high-fat diet (HFD) ameliorates hyperglycemia and insulin resistance, improves glucose homeostasis, and protects against steatosis, whereas...
BACH transcription factors in innate and adaptive immunity
May 2, 2017 · BTB and CNC homology (BACH) proteins are transcriptional repressors of the basic region leucine zipper (bZIP) transcription factor family. BACH proteins have widespread roles in immunological...
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