Jun 22, 2022 · What is Loeys-Dietz syndrome? Loeys-Dietz (LOW-eez DEETS) syndrome is a rare connective tissue disease. A gene change or mutation causes the disease. Loeys-Dietz syndrome can affect many organs such as the heart, blood vessels, bones, eyes and skin, causing life-threatening problems. Cleveland Clinic is a non-profit academic medical center.

Feb 28, 2008 · Loeys-Dietz syndrome (LDS) represents a wide phenotypic spectrum in which affected individuals may have various combinations of clinical features ranging from a severe syndromic presentation with significant extravascular systemic findings in young children to predominantly thoracic aortic aneurysm/dissection occurring in adults.

What is Loeys-Dietz Syndrome? Loeys-Dietz syndrome is a connective tissue disorder that was first described in 2005. Most individuals with this disorder have craniofacial features that include hypertelorism (widely spaced eyes) and a bifid or broad uvula.

Loeys–Dietz syndrome (LDS) is an autosomal dominant genetic connective tissue disorder. It has features similar to Marfan syndrome and Ehlers–Danlos syndrome. [3] [4] [5] The disorder is marked by aneurysms in the aorta, often in children, and the aorta may also undergo sudden dissection in the weakened layers of the wall of the aorta.

Loeys-Dietz syndrome (LDS) is a genetic disorder that affects the connective tissue in the body. The disorder was first observed and described by Dr. Bart Loeys and Dr. Hal Dietz at the Johns Hopkins University School of Medicine in 2005. Since then, other groups around the world have described additional genetic causes of Loeys-Dietz syndrome.

Sep 18, 2018 · Loeys-Dietz syndrome is a genetic disorder affecting the connective tissue. We'll explain the types, its symptoms, and what you can do to manage it.

Loeys-Dietz syndrome (LDS) is a genetic disorder that affects the connective tissue in the body. The disorder was first observed and described by Dr. Bart Loeys and Dr. Hal Dietz at the Johns Hopkins University School of Medicine in 2005. Since then, other groups around the world have described additional genetic causes of Loeys-Dietz syndrome.

Loeys-Dietz syndrome is a connective tissue disorder that causes aortic aneurysms, widely spaced eyes (hypertelorism), cleft palate and/or split uvula (the little piece of flesh that hangs down in the back of the mouth) and twisting or spiraled arteries (arterial tortuosity).

Mar 18, 2025 · Loeys-Dietz syndrome (LDS) presents with a wide range of signs and symptoms, and while some individuals have prominent physical features (like widely spaced eyes, cleft palate, or skeletal abnormalities), others may not. However, the most serious concerns with LDS are vascular issues, such as aneurysms and arterial dissections, which can occur ...

Loeys-Dietz syndrome is a genetic condition of connective tissue which causes changes in the heart, blood vessels, bones, joints, skin, and internal organs, such as the intestines, spleen, and uterus.