Finally, pathways such as Wnt signaling are very complex and involve a number of different ligands, receptors and endogenous antagonists and the activation of distinct intracellular signaling ...

Figure. Integrating sclerostin actions with Wnt/LRP (low-density lipoprotein [LDL] receptor–related proteins) signaling programs in aortic physiology. Wnt signaling cascades continue to emerge as key ...

This indicates that GLP-1 receptor agonists lead to greater reduction in overall body fat than that in muscle mass, resulting in an overall body fat percentage decrease of around 4.5%.

Forbes contributors publish independent expert analyses and insights. Asif Burhan is a freelance journalist who covers women's soccer.

In the canonical pathway, Wnt ligands bind to Frizzled receptors, stabilizing β-catenin, which accumulates in the cytoplasm and enters the nucleus. In the nucleus, β-catenin activates downstream genes ...

In a surprising discovery, scientists have found that the heart possesses 'sweet taste' receptors, similar to those on our tongues, and that stimulating these receptors with sweet substances can ...

Additionally, their research may explain why high consumption of artificially sweetened beverages is linked to arrhythmogenesis, or an irregular heartbeat. Not only are these sweet taste receptors ...

Interestingly, TCF7L2 and β-catenin (β-cat), another effector of Wnt signaling pathway, may also mediate the function of the incretin hormones as well as the expression of their receptors in ...

Frizzleds (Fzd) are the primary receptors for Wnt morphogens, which are essential regulators of stem cell biology, yet the structural basis of Wnt signaling through Fzd remains poorly understood. Here ...

Wnts regulate trafficking of DCs to tumor and tumor-draining lymph nodes (TDLNs) by regulating the expression of chemokine receptors CCR5, XCR1, and CCR7. Within the TME, DC-intrinsic Wnt signaling ...