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Nature3d
Development trends for therapeutic antibody fragments
In addition, the variety of molecular types of fragments has increased over time, with Fab the only fragment type first studied in the clinic before 1996. Interestingly, of these Fab candidates ...
Nature6d
The Goldilocks conditions applied to T cell development
The ligand for the T cell receptor (TCR) is a stable complex of a peptide fragment bound in the groove of a major histocompatibility complex (MHC) molecule. The peptides presented by MHC are ...
C&EN5d
Structure of the p300 Histone Acetyltransferase Bound to Acetyl-Coenzyme A and Its Analogues
Toward this goal, a structure of p300 bound to a Lys-CoA bisubstrate HAT inhibitor has been previously elucidated, and the enzyme’s catalytic mechanism has been investigated. Nonetheless, many ...
C&EN3d
Quantifying Bound and Active Antibodies Conjugated to Gold Nanoparticles: A Comprehensive and Robust Approach To Evaluate Immobilization Chemistry
Get article recommendations from ACS based on references in your Mendeley library. Pair your accounts. Export articles to Mendeley Get article recommendations from ACS based on references in your ...
The Lancet6d
Advances in precision medicine for lupus nephritis: biomarker- and AI-driven diagnosis and treatment response prediction and targeted therapies
Dapirolizumab pegol (DZP) is a polyethylene glycol-conjugated anti-CD40L Fab fragment monoclonal antibody ... chimaeras (PROTACs), have become a research hotspot. The chemical structure of TPD ...