This review discusses critical molecular mechanisms by which exogenous particles (i.e., silica, asbestos, carbon nanotubes, titanium dioxide, aluminum-containing salts) and endogenous particles (i.e., ...

Various sources, including dead cells, tumor cells, DNA and retroviruses, and self-DNA, can release dsDNA into the cytoplasm, triggering cGAS activation. Upon binding to dsDNA, cGAS catalyzes the ...

Silica is a crucial mineral for maintaining the health of our bones, skin, and hair. It is highly recognized for enhancing collagen production, promoting joint health, and fortifying the immune ...

The cGAS-STING signalling pathway has a central role in the innate immune response to extrinsic and intrinsic sources of cytoplasmic dsDNA. At the core of this pathway is cGAS-dependent production of ...

In this important study, the authors investigate the biogenesis of extracellular vesicles in mycobacteria and provide several observations to link VirR with vesiculogenesis, peptidoglycan metabolism, ...

During the peer-review process the editor and reviewers write an eLife assessment that summarises the significance of the findings reported in the article (on a scale ranging from landmark to useful) ...

Shandong Key Laboratory of Oilfield Chemistry, School of Petroleum Engineering, China University of Petroleum (East China), Qingdao 266580, China Key Laboratory of Unconventional Oil & Gas Development ...