Introduction: Rare pathogenic variants in the PTPN11, KRAS, SOS1 and RAF1 genes are the main molecular causes of Noonan syndrome (NS). Most are dominant gain-of-function variants that cause an ...

Currently, the genetic workup of AML relies on fluorescence in situ hybridization (FISH), karyotyping and targeted next-generation sequencing panels. We hereby present two cases of AML, in which the ...

This is an outstanding new method using base editor technology for introducing precise mutations in zebrafish and medaka vertebrate model systems. The approach is some of the strongest evidence to ...

Most types of cancers are made up of heterogeneous mixtures of genetically distinct subclones. In particular, acute myeloid leukemia (AML) has been shown to undergo substantial clonal evolution ...