Laboratory analyses showed that the patient who developed AML had significant chromosomal abnormalities and mutations in the RUNX1 and PTPN11 genes typically associated with the development of the ...

Introduction: Rare pathogenic variants in the PTPN11, KRAS, SOS1 and RAF1 genes are the main molecular causes of Noonan syndrome (NS). Most are dominant gain-of-function variants that cause an ...

Chronic myelomonocytic leukemia (CMML) is a rare hematopoietic malignancy characterized by persistent monocytosis in peripheral blood and bone marrow dysplasia. 1 Originally categorized as a ...

Gene-engineered immune cell therapies have partially transformed cancer treatment, as exemplified by the use of chimeric antigen receptor (CAR)-T cells in certain hematologic malignancies. However, ...

The genetic basis of most traits is highly polygenic and dominated by non-coding alleles. It is widely assumed that such alleles exert small regulatory effects on the expression of cis-linked genes.

Combined, these findings show that CMA displays a broad targetability on multiple steps of the EMT process and indicate a substantial role of CMA in regulating the stability of pro-metastatic and ...

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