Figure 1: A systems perspective of the ERBB network. Like ERBB1, ERBB4 recruits GRB2, Shc and STAT5, whereas one isoform of ERBB4 (CYT-1) can activate PI3K 27. Although ERBB4 might not be able to ...

Fibroblast growth factor (FGF) signaling elicits multiple downstream pathways, most notably the Ras/MAPK cascade facilitated by the adaptor protein Grb2. However, the mechanism by which Grb2 is ...

The present study focuses on the role of Shp2 and Shc1 proteins in the recruitment of Grb2 in the events downstream of Fgfr activation. Strengths: The findings reveal that the juxtamembrane region of ...