All subjects were prescribed oral methotrexate and folic acid supplements (5mg once daily). It was necessary to establish that any trans-aminase change was due to methotrexate rather than one of ...

Methotrexate is a folic acid antagonist. It works by inhibiting the synthesis of purines and pyrimides and therefore interfering with DNA synthesis. Methotrexate affects rapidly dividing cells and ...

Leucovorin is turned into folic acid in your body. Folic acid can protect your healthy cells from the effects of high-dose methotrexate. When leucovorin is used for cancer, it can make certain ...

Folic acid can protect your healthy cells from the effects of high-dose methotrexate. When levoleucovorin is used for cancer, it can make certain chemotherapies work better to target and kill the ...