MTX exerts its chemotherapeutic effect by counteracting and competing with folic acid in cancer cells, resulting in folic acid deficiency and cell death. Normal cells are not spared; thus ...

Leucovorin is turned into folic acid in your body. Folic acid can protect your healthy cells from the effects of high-dose methotrexate. When leucovorin is used for cancer, it can make certain ...

To reduce neural tube defects (NTDs), the U.S. Food and Drug Administration (FDA) mandated that by January 1998 all enriched grain products should contain 140 μg of folic acid (FA)/100 g of flour.

Methotrexate is a folic acid antagonist. It works by inhibiting the synthesis of purines and pyrimides and therefore interfering with DNA synthesis. Methotrexate affects rapidly dividing cells and ...