AHA/ASA Journals8d
Myeloid Fatty Acid Metabolism Activates Neighboring Hematopoietic Stem Cells to Promote Heart Failure With Preserved Ejection Fraction
BACKGROUND: Despite the high morbidity and mortality of heart failure with preserved ejection fraction (HFpEF), treatment ...
Frontiers18d
PLX5622 Reduces Disease Severity in Lethal CNS Infection by Off-Target Inhibition of Peripheral Inflammatory Monocyte Production
PLX5622 is a CSF-1R inhibitor and microglia-depleting reagent, widely used to investigate the biology of this central nervous system (CNS)-resident myeloid population, but the indirect or off-target ...
Medscape25d
Morphine Stimulates CCL2 Production by Human Neurons
Human fetal brain tissue was obtained from women undergoing elective abortions, in accordance with informed-consent guidelines and a protocol approved by the Human Subjects Research Committee at ...
eLife1y
TLR7 activation at epithelial barriers promotes emergency myelopoiesis and lung antiviral immunity
Monocytes are heterogeneous innate effector leukocytes generated in the bone marrow and released into circulation in a CCR2-dependent manner. During infection or inflammation, myelopoiesis is ...
Frontiers2y
Macrophage malfunction in Triptolide-induced indirect hepatotoxicity
Antibodies against GAPDH (10494-1-AP), Myeloperoxidase (MPO, 22225-1-AP), CD11b (21851-1-AP), and F4/80 (28463-1-AP) were purchased from Proteintech (Chicago, IL, United States). HRP Conjugated ...
eLife3y
Subventricular zone/white matter microglia reconstitute the empty adult microglial niche in a dynamic wave
Microglia, the brain’s resident myeloid cells, play central roles in brain defense, homeostasis, and disease. Using a prolonged colony-stimulating factor 1 receptor inhibitor (CSF1Ri) approach, we ...