A team led by Prof. Wuran Wei from West China Hospital of Sichuan University and Dr. Dechao Feng from the Division of Surgery and Interventional Science at University College London has systematically ...

Brief high-intensity workouts can transform the body faster than traditional long gym sessions by unlocking unique biological ...

Hrvatin and colleagues explore the antiaging mechanisms of torpor, and separate the roles of metabolic rate and body temperature. The study demonstrates that hypothermia, and not hypometabolism ...

The mechanism study demonstrated that SESN2 was deeply involved in the regulation of AMPK and mTOR, whereas melatonin partially restored angiotensin II or H2O2 induced the activation of AMPK ...

Here, we found that inhibition of AMPK occurs during naïve transition with two conventional inhibitors of the MEK1 and GSK3β pathways. The accumulation of glycogen due to iGSK3β is responsible for ...

Mechanistically, Vam6 in iNKT cells is essential for Rab7a-Vam6-AMPK complex formation and thus for recruitment of AMPK to lysosome to activate AMPK, a negative regulator of mTORC1. Additionally, Vam6 ...

In a word, PI3K promotes the mTOR activates. Another important pathway of mTOR is regulated by AMPK. Firstly, AMPK directly phosphorylates Raptor to inhibit mTORC1 activity. Raptor is the downstream ...