G protein–coupled receptors (GPCRs) are a protein superfamily comprising >800 members that regulate numerous cellular and physiologic responses. GPCRs represent the largest class of therapeutic ...

Find more information on the Altmetric Attention Score and how the score is calculated. ADP-ribosylation of nuclear proteins is a critical feature of various DNA damage repair pathways. Histones, ...

The IGS and levels of proinflammatory cytokines after ex-vivo challenge with a Toll-like receptor 7/8 agonist were immediately decreased by E6742 treatment. The response rate of the British Isles ...

Background Anti-N-methyl-D-aspartate receptor encephalitis (NMDARE) is a severe autoimmune disorder with high morbidity and mortality. Current treatments have limitations including relapse, ...

The mineralocorticoid receptor plays a significant role in the development of chronic kidney disease (CKD) and associated cardiovascular complications. Classic steroidal mineralocorticoid receptor ...

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Objective— The platelet ADP receptors P2Y1 and P2Y12 play a pivotal role in platelet aggregation. There is marked interindividual variation in platelet response to ADP. We studied whether genetic ...

Get article recommendations from ACS based on references in your Mendeley library. Pair your accounts. Export articles to Mendeley Get article recommendations from ACS based on references in your ...

Get Instant Summarized Text (Gist) A novel GPS NMR method enabled precise tracking of motions within the β 1-adrenergic GPCR, revealing that the receptor exists in a dynamic equilibrium among ...

Now, scientists at the Salk Institute have pinpointed a set of transcription factors—estrogen-related receptors (ERRs)—as essential regulators of mitochondrial metabolism in skeletal muscle ...

In this phase 2, randomized, placebo-controlled trial, participants with narcolepsy type 1 received once- or twice-daily oveporexton (TAK-861), an oral orexin receptor 2–selective agonist ...

New research findings on oveporexton, a highly selective oral orexin receptor 2 agonist, in these patients are summarized in a short video.