Some drugs can activate AMPK, most prominently metformin, which is approved for diabetes and being trialed in dementia. Less well-known is aldometanib, developed by Lin’s team, which blocks aldolase, ...

Gut-Brain Connection. People who have CD83+ microglia in their brains also have HCMV (top left) and IgG4 (top right) in their ...

HSV-1 is a common virus. During infection, its DNA incorporates into host chromosomes, where it lies dormant. An estimated two-thirds of adults worldwide carry these latent HSV-1 genes. Previous work ...

Mutations in NPC1 cause Niemann-Pick Type C. Mice lacking NPC1 only in microglia have rampant neuroinflammation and impaired ...

I thank you for your response, for its thoughtfulness and thoroughness. The first round of a debate is most useful for isolating the crux. I therefore kindly ask for one more public round. This would ...

The first round of a debate is most useful for isolating the crux. I therefore kindly ask for one more public round. This would be most beneficial, not just for me, but also for the many Alzforum ...

Synaptic transmission is an energy hog. It requires neurons to tap ATP reserves to respond to incoming signals. How do they pull this off, thousands to millions of times per day? A new study ...