The 49ers came out firing on all cylinders in the first half of their loss to the Detroit Lions on Monday, but couldn’t ...

Isaac Guerendo, RB, SF (foot/hamstring) — Expected to play In Guerendo’s Week 16 absence, Patrick Taylor had eight carries for 24 yards, while WR Deebo Samuel had five carries for 25 yards. But ...

There are numerous player prop betting options on Isaac Guerendo for the 8:15 PM ET game Monday, which airs live on ABC/ESPN.

Guerendo took nine carries for 34 yards while bringing in all four targets for 65 receiving yards in Monday's 40-34 loss to the Lions. Guerendo made a successful return from a one-game layoff due to ...

San Francisco 49ers head coach Kyle Shanahan recapped the team's 40-34 loss to the Detroit Lions, evaluated the 49ers performance on "Monday Night Football" and shared injury updates on QB Brock Purdy ...

San Francisco 49ers host the Detroit Lions on Monday Night Football to disrupt the Lions' quest for the NFC's No. 1 seed.

The Detroit Lions will face the San Francisco 49ers in week 17 of the NFL season on Monday Night Football at Levi's Stadium on December 30th. WATCH ...

San Francisco 49ers TE George Kittle secured his 1,000-yard mark on the season with a 20-yard reception vs. the Lions.

The 49ers (6-9) have won so few they are vacating the NFC throne, having been eliminated last Sunday from playoff contention.

The Week 17 edition of Monday Night Football may not mean much for either the San Francisco 49ers or Detroit Lions, but it means plenty for bettors and fantasy ...

Experts have released new player stat projections alongside updated prop odds for Monday's Lions-49ers NFL Week 17 Monday ...

The National Football League injury report, as provided by the league (OUT: Player will not play; DOUBTFUL: Player is unlikely to play; QUESTIONABLE: Player is not certain to play; DNP: did not ...