eLife9d
Genome organization by SATB1 binding to base-unpairing regions (BURs) provides a scaffold for SATB1-regulated gene expression
Mammalian genomes are organized by multi-level folding, yet how this organization contributes to cell type-specific transcription remain unclear. We uncovered that the nuclear protein SATB1 ...
eLife4d
Ezh2 Delays Activation of Differentiation Genes During Normal Cerebellar Granule Neuron Development and in Medulloblastoma
Using an unbiased approach, this important study discovered a role of Ezh2 in the differentiation of granule neuron precursors, the cell of origin for Shh group of medulloblastoma. Furthermore, the ...
Le Lézard8d
ImmunityBio Announces First Dosing of Recombinant BCG (rBCG) in the U.S. and 60 Sites Are in the Process of Launching
ImmunityBio, Inc. , a leading immunotherapy company, today announced U.S. Urology Partners, one of the nation's largest independent providers of urology and related specialty services, is one of the ...
Frontiers18d
Targeting tumor-associated macrophages with STING agonism improves the antitumor efficacy of osimertinib in a mouse model of EGFR-mutant lung cancer
Introduction: Despite the impressive clinical response rate of osimertinib, a third-generation EGFR-TKI, as a frontline treatment for patients with EGFR-mutant non-small-cell lung cancer (NSCLC) or as ...
gut.bmj23d
Dual role of tumour-infiltrating T helper 17 cells in human colorectal cancer
The potential contribution of tumour-infiltrating Th17 to anti-tumour immune responses should not be disregarded ... Worthington Biochemical Corporation and 0.2 mg/mL DNAse I, Sigma-Aldrich, for 1 h ...
gut.bmj18d
Primary sclerosing cholangitis is characterised by intestinal dysbiosis independent from IBD
PSC diagnosis followed established guidelines and was based on symptoms and/or signs of chronic cholestatic liver injury, negative anti-mitochondrial autoantibodies ... was followed with the exclusion ...
Wired7d
The Anti-DEI Agenda Is Reprogramming America
President Trump’s anti-DEI playbook doesn’t just affect the makeup of America’s workplaces. It also impacts cultural production. Just ask Netflix’s former head of diversity. If you buy ...
Fox News25d
Anti-ICE activists disrupt LA operations, post photos, names and phone numbers of agents
Flyers showing the names, pictures, and phone numbers of Immigration and Customs Enforcement (ICE) agents have surfaced in a Southern California neighborhood. Multiple federal law enforcement ...
AOL9d
20 Anti-Inflammatory Dinners in 25 Minutes
In just 25 minutes, you can whip up one of these tasty anti-inflammatory dinners, from a veggie-packed salad to a plate of creamy pasta. Whatever you choose will include plenty of nutrient-dense ...
USA Today10d
Anti-Muslim discrimination reached record high in 2024, report finds
"Last year, what we saw is people being targeted for their viewpoint, primarily anti-apartheid, anti-genocide viewpoints." Anti-Muslim racism 'thrives in corporate America' More than 1,300 ...
Fox News12d
ICE agents arrest anti-Israel activist who led protests on Columbia University campus for months
An anti-Israel activist, who students claim was a leader of protests and encampments on the Columbia University campus in New York City for months, has been arrested by U.S. Immigration and ...
The Hill29d
Group finds anti-Asian hate surging following Trump election
Anti-Asian hate surged online following President Trump’s November victory, with South Asian communities targeted the most, according to data from Stop AAPI Hate. In a report released Thursday ...