This variability may reflect the heterogeneous nature of autoantibodies targeting GPIb/V/IX, GPIIb/IIIa and other platelet-related antigens. In addition to direct pathogenic effects of antibodies ...

From the Cox Laboratory for Biomedical Engineering, Rice University, Houston, Tex (N.A.T, J.L.M., L.V.M.); the Department of Medicine, Baylor College of Medicine ...

A newly discovered alloantigen on platelet glycoprotein IIb/IIIa, designated Dik ... Functional validation using HEK293 cells transfected with mutant GPIIb and wild-type GPIIIa confirmed that anti-Dik ...

4 Interestingly, in both the EPILOG (Evaluation in PTCA to Improve Long Term Outcome with Abciximab GPIIb/IIIa Blockade) and EPISTENT (Evaluation of Platelet IIb/IIIa Inhibitor for Stenting) trials, ...

Platelets are small types of blood cells that prevent excessive bleeding. It’s possible to develop low or high platelet counts related to a number of health conditions. Platelets are one of the ...

For clinical questions that were not addressed by the AABB and the International Collaboration for Transfusion Medicine Guidelines (the use of leukoreduction and platelet transfusion in solid tumors ...

The currently available antiplatelet drugs target key steps of platelet activation including thromboxane A 2 synthesis, ADP-mediated signaling, and glycoprotein IIb/IIIa-mediated platelet aggregation.

Take platelet-rich plasma (PRP) therapy, for instance. Known as the “vampire facial”, it became famous in 2013 when Kim Kardashian posted a now-iconic, blood-covered selfie during the procedure.

[59] Larger trials are necessary to confirm the existence of platelet resistance to prasugrel and to describe the possible underlining mechanisms. Elinogrel (PRT060128 or PRT128) (Figure 3 ...

While glycoprotein (GP) IIb/IIIa inhibitors have been widely studied in ischemic stroke, cangrelor remains less explored. Objective To evaluate the safety and efficacy of cangrelor compared with GPIIb ...

Islam Makhachev’s next fight will be against Jack Della Maddalena in the welterweight class, rather than IIia Topuria in the lightweight class, after the Russian vacated his lightweight title to ...