Figure 1: A systems perspective of the ERBB network. Like ERBB1, ERBB4 recruits GRB2, Shc and STAT5, whereas one isoform of ERBB4 (CYT-1) can activate PI3K 27. Although ERBB4 might not be able to ...

1). Although attention has historically focused on Grb2-mediated recruitment to receptor tyrosine kinases as a means of localizing SOS to the plasma membrane, recent work has revealed increasing ...