rheumatologyadvisor13d
Low Baseline Disease Activity Predicts MTX Monotherapy Success at 1 Year in RA
Predictors of MTX monotherapy treatment success among patients with RA include low disease activity, normal body weight and ESR levels, and fewer tender joints.
Medscape3d
Role of Methotrexate in Juvenile Idiopathic Arthritis
No writing assistance was utilized in the production of this manuscript. Methotrexate (MTX) is the widely agreed upon first-choice second-line agent to treat juvenile idiopathic arthritis (JIA ...
Medscape7d
Synergistic Effect of Antiangiogenic Nanotherapy Combined with Methotrexate in the Treatment of Experimental Inflammatory Arthritis
p < 0.05. **p < 0.001 compared with no Tx group. Fum-NP: Fumagillin-nanoparticle; MTX: Methotrexate; Tx: Treatment. *p < 0.01. **p < 0.001 compared with no Tx group. Fum-NP: Fumagillin ...
Daily14d
Methotrexate first line, viable treatment option for effective mycosis fungoides, finds study
A new study published in the Journal of the European Academy of Dermatology and Venereology found that methotrexate (MTX) has ...
Too Old to Operate13d
CXCL13 as a Biomarker for MTX Response in Early RA
The following is a summary of “High serum levels of CXCL13 predict lower response to csDMARDs in both ACPA-positive and ACPA-negative early rheumatoid arthritis,” published in the October 2024 issue ...
Business Wire25d
DeepCure to Present First Ex Vivo Rheumatoid Arthritis Patient Data for Selective BRD4 (BD2) Inhibitor DC-9476 at ACR Convergence 2024
will share ex vivo data demonstrating the efficacy of DC-9476 in cells from RA patients that have had an inadequate response to methotrexate (MTX-IR). RA affects approximately 1% of the population ...
BMJ10d
A randomised controlled trial of etanercept and methotrexate to induce remission in early inflammatory arthritis: the EMPIRE trial
4 The York Hospital, York Hospitals NHS Foundation Trust, UK 5 Department of Rheumatology, Darlington Memorial Hospital, County Durham and Darlington NHS Foundation Trust, UK Objective To compare the ...
BMJ10d
Humoral immune response to vaccines in patients with rheumatoid arthritis treated with tocilizumab: results of a randomised controlled trial (VISARA)
Methods Patients with RA with inadequate response/intolerance to one or more anti-tumour necrosis factor-α agents were randomly assigned (2:1) to TCZ 8 mg/kg intravenously every 4 weeks plus ...
Daily26d
Methotrexate Treatment may jeopardize immune responses of COVID-19 vaccination in Rheumatoid Arthritis Patients: Study
Researchers have discovered that methotrexate (MTX) therapy may substantially diminish vaccine-induced CD4 T cell activation resulting in decreased antibody responses in rheumatoid arthritis (RA) ...
Frontiers25d
Novel genomic variants influencing methotrexate delayed clearance in pediatric patients with acute lymphoblastic leukemia
Background: Methotrexate (MTX) is the primary drug used in the treatment of pediatric acute lymphoblastic leukemia (ALL). However, some patients exhibit delayed clearance of high-dose (HD) MTX, which ...
Monthly Prescribing Reference11d
Arthritis Treatments: DMARDS and Other Immune Modulators
Key: AS = Ankylosing spondylitis; DMARD = disease-modifying antirheumatic drug; ERA = Enthesitis-related arthritis; JPsA = Juvenile psoriatic arthritis; MTX = methotrexate; nr-axSpA = non ...