Kidney fibrosis, a common endpoint of chronic kidney disease (CKD), is strongly linked to aging, with cellular senescence ...

An unprecedented international effort to decode how cells manage the transport of chemical substances has culminated in four ...

The human body and its organs are composed of a wide variety of cell types. Although all cells contain the same genes, they ...

What if we could reprogramme the TME itself? Cutting-edge research suggests that engineered mesenchymal stem cells (MSCs) ...

In research models, B7-33 has been associated with reduced fibrotic markers and improved tissue architecture. These findings ...

For example, it is unclear why antitumour ... No matter how we perturbed interferon-γ signalling in these cells, its antitumour effects persisted. We assembled an array of mouse lines that ...

This study presents a valuable finding on how the locus coeruleus modulates the involvement of medial prefrontal cortex in set shifting using calcium imaging. The evidence supporting the claims was ...

Peptidomimetics are synthetic analogs that retain the essential structure and function of peptides but with chemical ...

The changes affected, for example, cellular survival ... influence gene regulation in olfactory mucosa cells altering PI3K/AKT signaling, Environment International (2025). DOI: 10.1016/j.envint.

PME-1 is a protein that modifies other proteins by removing methyl groups, but high levels of PME-1 are observed in some diseases, including Alzheimer's disease (AD) and cancer.