‡ Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CAS), Shanghai 201203, China § CAS Key Laboratory of ...

G protein-coupled receptors (GPCRs) transduce information encoded by external stimuli into an appropriate cell output and as such play a key ... including how they dynamically signal in space and time ...

Stem and progenitor cell-mediated gene delivery is emerging ... cells can be used to deliver therapeutic genes, cDNAs or siRNAs selectively to tumor foci. We and others envision that this inherent ...

Innovative delivery techniques, including high-tech nanoparticles and electroporationdevices, may convey more gene therapies into the clinic.