Nature18d
Blocking CD40-TRAF6 interactions by small-molecule inhibitor 6860766 ameliorates the complications of diet-induced obesity in mice
CD3, CD8, CD25, FoxP3, F4/80, CD11b, CD11c, Gr-1 (eBioscience ... EpAT and ScAT was performed for CD45 (BD) and on EpAT for CD68 (Bio-Rad). Five micrometre frozen sections of the liver were ...
Frontiers12d
Discrepancies between human and murine model cerebral aneurysms at single-cell resolution
Background: The murine model of cerebral aneurysm (CA) serves as a prevalent tool for investigating the molecular underpinnings of CA. However, the extent to which the CA murine model aligns with that ...
AHA/ASA Journals8d
Myeloid Fatty Acid Metabolism Activates Neighboring Hematopoietic Stem Cells to Promote Heart Failure With Preserved Ejection Fraction
BACKGROUND: Despite the high morbidity and mortality of heart failure with preserved ejection fraction (HFpEF), treatment ...
Medscape25d
Morphine Stimulates CCL2 Production by Human Neurons
Human fetal brain tissue was obtained from women undergoing elective abortions, in accordance with informed-consent guidelines and a protocol approved by the Human Subjects Research Committee at ...
gut.bmj2d
Signatures of tumour immunity distinguish Asian and non-Asian gastric adenocarcinomas
Inflammatory cell markers CD66b and CD68 also exhibited significant cohort differences (p<0.05). Exploratory analyses revealed a significant relationship between tumour immunity factors, geographic ...
Frontiers18d
PLX5622 Reduces Disease Severity in Lethal CNS Infection by Off-Target Inhibition of Peripheral Inflammatory Monocyte Production
PLX5622 is a CSF-1R inhibitor and microglia-depleting reagent, widely used to investigate the biology of this central nervous system (CNS)-resident myeloid population, but the indirect or off-target ...
eLife18d
Deciphering the Preeclampsia-Specific Immune Microenvironment: The Role of Pro-inflammatory Macrophages
(A) Distribution of the CD11b + immune cells in group analyzed using t-SNE. (B) Heatmap showing the expression levels of markers in the CD11b + cells. (C) Scatter dot plots showing the frequencies of ...
eLife11d
Targeting IRE1α improves insulin sensitivity and thermogenesis and suppresses metabolically active adipose tissue macrophages in male obese mice
Samples were stained using the following antibodies: PerCP-conjugated anti-mouse CD45 (Cat# 110725, RRID:AB_893347), FITC-conjugated anti-mouse F4/80 (Cat# 123108, RRID:AB_893502), PE-conjugated ...
BMJ18d
Phosphatidylinositol 3-kinase delta pathway: a novel therapeutic target for Sjögren’s syndrome
30 The following antibodies were used: for mouse CD45 clone 30-F11, CD19 clone eBio1D3 and CD3e clone ebio500A2 (from eBiosciences) and for humans CD3 polyclonal rabbit or monoclonal mouse (Dako), ...