In the above studies, we identified a chemokine, CXCL16, which represents the only CXC chemokine to date that exists in a transmembrane form. CXCL16 was expressed on T cell zone DCs and sinus ...

Their transmembrane regions, which span the cell membrane, are likely to rotate on their long axes, perpendicular to the membrane. Ligand binding to the extracellular part of the receptor induces ...

a transmembrane ligand expressed on osteoblasts/stromal cells, that binds to RANK, a transmembrane receptor on hemopoietic osteoclast precursor cells. The interaction of RANK and RANKL initiates a ...

"Reversible ligand binding such as this is key to maintaining homeostasis within the body via the regulation of transmembrane ion channels. The highly regulated orientation of VF allowed for this ...

Their transmembrane regions, which span the cell membrane, are likely to rotate on their long axes, perpendicular to the membrane. Ligand binding to the extracellular part of the receptor induces ...

it interacts extracellularly with the Notch transmembrane ligand which initiates proteolytic cleavage of the receptor and consequently the Notch intracellular domain (Notch ICD or NICD ...

Ligand-gated ion channels are a group of intrinsic transmembrane proteins that are opened by the binding of a neurotransmitter. The ligands binds to a site, which is distinct from the ion ...

1 The transmembrane-spanning α helices of the protein are separated ... However, many human GPCRs have unknown functions; scientists are still elucidating the ligand-binding capability and function of ...

(a) Binding of a ligand to its target protein (top ... extends CETSA to the traditionally difficult-to-study transmembrane proteins. The team performed a careful investigation on the utility ...