Talin is a protein that plays an important role in the immune system by activating integrins, receptors that help cells ...

Figure 1: Integrin beta-1 is increased in activated HSCs and required for phenotype and function. Figure 2: Integrin beta-1 is required for multiple pro-fibrotic features in activated HSCs.

We report a novel mode of integrin–RTK cooperation, which we term ‘inside-in signalling’. Figure 1: c-Met and β1-integrin co-internalize in a molecular complex in both adherent cells and ...

Integrin beta-6 is a cell surface receptor that interacts with the ECM ... Methods: SGNB6A-001 (NCT04389632) is a phase 1, first-in-human, open-label, multicenter study designed to evaluate the safety ...

The OCU200 Phase 1 clinical trial is a multicenter ... anti-VEGF agent by binding to integrin receptors; and transferrin, which targets the drug to the choroid and retina by binding transferrin ...