Growth of Kym-1 rhabdomyosarcoma cells depends on endogenous receptor tyrosine ... pathways in Kym-1 cells. In accordance with a caspase-independent cytostatic action, TNF downregulated IR kinase ...

Receptor tyrosine ... of ATP-competitive tyrosine kinase domain inhibitors. Biased ligands hold therapeutic promise due to their ability to selectively modulate beneficial signaling cascades ...

DNA methylation, RTK pathway changes, and KRAS amplifications may drive resistance to sotorasib plus panitumumab in KRAS G12C ...

The Met receptor tyrosine kinase is the prototypic member of a ... and while normal HGF/SF-Met signaling is required for embryonic development, abnormal Met signaling has been strongly implicated ...

View all available purchase options and get full access to this article. Corresponding author: Ben Ho Park, MD, PhD, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of ...

The Understanding the Pathway article by Wiestner, entitled "Targeting B-Cell Receptor Signaling for Anticancer Therapy: The Bruton's Tyrosine Kinase Inhibitor Ibrutinib Induces Impressive Responses ...

The pathway plays a wide variety of roles ... membrane-anchored dimerization systems in activating the receptor tyrosine kinase signaling in live Xenopus embryos. Here, we determine if this ...

Protein tyrosine ... BCR-ABL kinase domain, including Thr315Ile, can decrease or abolish the inhibitory effect of the drug (mechanism C). Constitutive activation of a signaling pathway downstream ...

This pathway mainly uses growth factors as the initial signaling molecule required for activation. These growth factors bind to tyrosine kinase receptors in the cell membrane, which activates the ...

Because the signaling pathways activated by several tyrosine kinase receptors have been shown to be involved in lung fibrosis, it has been suggested that the inhibition of these receptors may slow ...

Researchers at the NYU Pain Research Center have found a new receptor for nerve growth factor that plays an important role in pain signaling ... tropomyosin receptor kinase A, or TrkA.

One of the novel pathways under investigation is the inhibition of Bruton tyrosine kinase, a cytoplasmic tyrosine ... Involvement of Fc receptors in disorders of the central nervous system.