74 As renin has an upstream role in the RAAS cascade, blockade of renin might inhibit the detrimental effects of both angiotensin II and aldosterone, resulting in additive beneficial haemodynamic ...

As renin inhibition acts at the top of the RAAS cascade, this mechanism has been proposed to offer advantages over existing modes of RAAS blockade. The RAAS is also considered to be a major factor ...

However, SARS-CoV-2 reduces ACE2 expression, thus leading to lung injury by a cascade of inflammation. ACE inhibitors and ARBs may rebalance the RAAS pathway to favor ACE2 function to oppose the ...