and prilocaine) have been developed. Though extremely rare, some people are allergic to amide local anesthetics. In these cases, novocaine is often used as a substitute because it's ester-based.

cross-reaction groupings among amide anesthetics are not yet well established. Prilocaine was implicated in cross-reactions with lidocaine, articaine, mepivacaine, dibucaine, and bupivacaine.

Lidocaine is classified in the amide group of anesthetics, along with mepivacaine, bupivacaine, etidocaine and prilocaine ... an anesthetic from the ester group could be used as an alternative ...