Figure 6: IL4R-IbαTg platelets exhibit ligand-free GPIb–IX signalling and fast clearance ... similar in two key aspects. First, the signal of ligand binding is transmitted as a mechanical ...

and RhoA (stop-signal) at the centre of a molecular checkpoint downstream of GPIb that controls transendothelial platelet biogenesis. Our results may open new avenues for the treatment of platelet ...

Receptor stimulation and the tyrosine phosphorylation of key signaling molecules underpin platelet activation in both hemostasis and cardiovascular disease. A lack of nucleus and low mRNA levels ...

Inflammation plays a crucial role in the development of various diseases, including cancer, allergic diseases, such as asthma, and cardiovascular diseases, such as atherosclerosis and heart failure.

Dr. Woulfe's research interests focus primarily on the intracellular signaling mechanisms of platelet activation and how signaling in platelets contributes to thrombosis in vivo. Agonists that extend ...

Using human platelet-rich plasma, the researchers found that when certain signaling molecules were inhibited, spreading was blocked but not clot contraction, and the opposite was true as well.

Results from the study suggest that inducing PDGF signaling in tumor-reactive NK cells should benefit NK cell expansion and persistence and contribute to the enhanced effector function in NK cell ...

Since 2007, his laboratory has focused on identifying the key factors that determine the efficiency of thrombin signaling through protease activated receptor 4 (PAR4) on platelets and other cells. The ...

H 2 S modulates platelet autophagy and functions possibly via the PDGFR-α/PI3K/Akt/mTOR signaling pathway. The role of platelet autophagy in cirrhotic thrombocytopenia (CTP) remains unclear.

Platelet-derived growth factor (PDGF) signaling, besides other growth factor-mediated signaling pathways like vascular endothelial growth factor (VEGF) and epidermal growth factor (EGF), seems to ...

BSS is caused by a deficiency in the GPIb-IX-V complex, which is an important platelet receptor complex that binds to the von Willebrand factor (vWF). The tendency to bleed profusely from wounds ...