The P2X7 receptor is a crucial component of cellular communication with a pivotal role in health and disease management, impacting conditions like anxiety, depression and chronic inflammation.

In a recent study posted to the bioRxiv* preprint server, researchers demonstrated that the soluble P2X7 receptor is increased in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 ...

Study: Characterization of the central nervous system penetrant and selective purine P2X7 receptor antagonist JNJ-54175446 in patients with major depressive disorder. Image Credit: fizkes ...

A new international study, led by researchers from FutureNeuro, RCSI University of Medicine and Health Sciences and collaborators worldwide, has identified the P2X7 receptor as a critical factor in ...

More information: Akira Karasawa et al. Structural basis for subtype-specific inhibition of the P2X7 receptor, eLife (2016). DOI: 10.7554/eLife.22153 Journal information: eLife ...

Published in Theranostics, the study highlights the important role played by a receptor in the brain called P2X7. It suggests how we could both reduce epilepsy risk and predict which patients are ...

Golgi Neurosciences srl and Breye Therapeutics ApS have established a collaboration to develop Golgi’s P2X7 receptor antagonist program for retinal disorders. The companies have now closed the ...

2,4-Dihydro-3h-1,2,4-triazol-3-one P2X7 receptor antagonists have been reported in an Axxam SpA patent as potentially useful for the treatment of cognitive, eye, gastrointestinal, genitourinary and ...