In summary, this study sheds new light on the mechanisms of metabolic control of T-cell fate by epigenetic mechanisms and opens up new opportunities for the prevention and treatment of EAE and ...

He and his colleagues will also explore whether cancer cells adapt to hijack the metabolism and epigenetic regulation of T cells to push them into a less persistent, terminal effector state.

Exhausted T cells have idiosyncratic metabolic demands and are ... This involves orchestrated epigenetic changes and transcriptional regulation. After antigen recognition and activation, T cells ...

A recent Science study explored how intranuclear metabolic enzymes establish the link between locus-specific epigenetic reprogramming of T cells and nutrient availability. Persistent antigen ...

The activation of a T cell causes epigenetic changes that can influence cell fate and metabolism. Changes in metabolism can provide substrates, like acetyl-CoA and methyl groups, which can further ...

1 Animal models: memory-like cells capable of protective recall develop in mice infected with MCMV After infection, memory NK cells and CD8+ T cells ... layers of epigenetic regulation of ...

This advantage can become a drawback, though, as this epigenetic regulation can be more easily ... the effects of various chemical products on cell metabolism. The research has focused on ...

stem cell biology, developmental biology, gene regulation and epigenetics, cancer biology, immunity and infection, neuroscience, disease-specific animal models, gene and cell-based therapies ...

The reduction of the immune response and the initiation of tissue healing is partly achieved by tissue-resident immune cells, in particular regulatory T ... of epigenetics is the regulation ...