To determine whether CLL cells had altered lysosomes, we investigated sphingolipid metabolism as the lysosome is a hub for lipid metabolism. We found that CLL cells had more lysosomes, increased ...

Because of the organelle's ability to control fat metabolism, University of Virginia biologist Eyleen O'Rourke predicts that lysosomes could someday serve as therapeutic targets for metabolic ...

"Historically, it has been difficult to identify lysosomal lipid transporters, limiting our understanding of the role of the lysosome in lipid metabolism and disease," said Professor David Silver ...

Metabolism breaks down in cells lacking retromer ... In the May 29 Nature Communications, they reported that cell membrane proteins are missorted, lysosomes get bloated with undigested cargo, ...

Lysosomes are membrane-bound organelles in cells that act as recycling centers—breaking down waste materials, damaged organelles, and unwanted molecules using powerful digestive enzymes ...

Once thought of as having one simple job within cells, researchers continue to learn more about the importance of organelles called lysosomes. An organelle is a small structure in a cell that is ...

Lysosomes are membrane-bound organelles in cells that act as recycling centers—breaking down waste materials, damaged organelles, and unwanted molecules using powerful digestive enzymes.

These rare neurodegenerative diseases are characterized by the dysfunction of lysosomes, cellular organelles that break down various substances ready for disposal, including proteins, nucleic ...

The lysosome is a small membrane bound organelle that can be found in most animal cells. It was once thought that these little sacs were like recycling centers that could take up cellular waste ...

For the first time, the pathway through which cells repair damaged lysosomes has been observed and described. Lysosomes are the recycling center of a cell, where molecular waste is degraded into the ...