To accomplish these tasks, a bulky complex of proteins called the pre-initiation complex is assembled each time transcription begins. Together, the proteins in the pre-initiation complex find a gene’s ...

The paper is titled "Structural visualization of key steps in human transcription initiation." Co-authors are Yuan He, Jie Fang and Dylan Taatjes. The fundamental process of life by which ...

During transcription initiation, a large, multi-molecular machinery assembles on the promoter of a gene, to enable proper positioning of the RNA Polymerase enzyme and commence accurate mRNA synthesis.

If DNA is a book, then how is it read? Learn more about the DNA transcription process, where DNA is converted to RNA, a more portable set of instructions for the cell. The process of transcription ...

Figure 1: Rad26 helps Pol II to discriminate among different transcription obstacles. Figure 2: Cryo-electron microscopy structure of the Pol II EC bound to Rad26. Figure 3: Rad26 binds to the ...

Shawna was an editor at The Scientist from 2017 through 2022. She holds a bachelor's degree in biochemistry from Colorado College and a graduate certificate and science communication from the ...

"Each gene was like a single word. However, there was a piece of critical information lacking: transcription initiation sites for individual genes." Transcription initiation sites are locations in ...

The findings, captured within 500 milliseconds of RNAP mixing with DNA, shed light on fundamental mechanisms of transcription, and answer long-standing questions about the initiation mechanism and ...