The use of high-dose methotrexate (HD-MTX) has improved survival rates. This article describes the experience of a patient treated with HD-MTX and outlines the essential aspects of care for the ...

The importance of high-dose methotrexate as the backbone of induction chemotherapy for primary central nervous system lymphoma (PCNSL) is widely accepted. However, multiple dosing strategies have ...

Initially 12g/m 2 IV infusion over 4 hours; may be increased to 15g/m 2; see literature for leucovorin rescue dosing with high-dose methotrexate. Be fully familiar with this drug's toxicity before ...

Leucovorin is turned into folic acid in your body. Folic acid can protect your healthy cells from the effects of high-dose methotrexate. When leucovorin is used for cancer, it can make certain ...

Methotrexate is generally well tolerated in doses given to treat ectopic pregnancy. High-dose methotrexate has been associated with bone marrow suppression, hepatotoxicity, stomatitis, pulmonary ...

Azathioprine and methotrexate are both options for maintenance ... is based largely on the use of cyclophosphamide and high-dose corticosteroids for the induction of remission in patients with ...