GiGA1 preferentially activates a subset of GIRK channels, those containing the GIRK1 and GIRK2 subunits, most commonly found in the brain. GiGA1 also activates natively expressed GIRK channels in ...

That work extends the group's 2007 study showing that when SNX27 proteins capture GIRK channels, reducing the number of channels at their rightful destination, the cell membrane. "We were curious ...

Figure 1: The structure of GIRK channels and SK channels. A combination of electrophysiological and high-resolution immunoelectron microscopic approaches, as well as animal models, has recently ...

In response to incoming signals, these channels open up, creating many little "potassium leaks" and as a result the signal fizzles. GIRK channels (short for G-protein-coupled inwardly rectifying ...

The role of heterotetrameric potassium channels in the onset of a seizure Four mammalian GIRK channel subunits comprise heterotetrameric channels. The subunit combinations found in the brain are ...

They also found that a potassium channel called GIRK, or G protein-activated inward rectifying potassium channel, is constantly active in mature dentate granule cells, and this made the neurons ...

Hablitz, LM, Molzof, H., Abrahamsson, KE, Cooper, JM, Prosser, RA and Gamble, KL (2015). GIRK channels mediate the nonphotic effects of exogenous melatonin. J ...

In this article, the authors wrote: “Deletion of RGS7 in mice dramatically sensitizes GIRK responses to GABAb receptor stimulation and markedly slows channel deactivation kinetics. Enhanced ...

They also found that a potassium channel called GIRK, or G protein-activated inward rectifying potassium channel, is constantly active in mature dentate granule cells, and this made the neurons ...