Figure 1: The structure of GIRK channels and SK channels. A combination of electrophysiological and high-resolution immunoelectron microscopic approaches, as well as animal models, has recently ...

GiGA1 preferentially activates a subset of GIRK channels, those containing the GIRK1 and GIRK2 subunits, most commonly found in the brain. GiGA1 also activates natively expressed GIRK channels in ...

The role of heterotetrameric potassium channels in the onset of a seizure Four mammalian GIRK channel subunits comprise heterotetrameric channels. The subunit combinations found in the brain are ...

In response to incoming signals, these channels open up, creating many little "potassium leaks" and as a result the signal fizzles. GIRK channels (short for G-protein-coupled inwardly rectifying ...

They also found that a potassium channel called GIRK, or G protein-activated inward rectifying potassium channel, is constantly active in mature dentate granule cells, and this made the neurons ...

In this article, the authors wrote: “Deletion of RGS7 in mice dramatically sensitizes GIRK responses to GABAb receptor stimulation and markedly slows channel deactivation kinetics. Enhanced ...

Hablitz, LM, Molzof, H., Abrahamsson, KE, Cooper, JM, Prosser, RA and Gamble, KL (2015). GIRK channels mediate the nonphotic effects of exogenous melatonin. J ...