Northwestern Medicine scientists have identified a critical checkpoint in transcription elongation, the process of synthesizing RNA from a DNA template, according to findings published in ...

A little-studied factor known as the Little Elongation Complex (LEC) plays a critical and previously unknown role in the transcription of small nuclear RNAs (snRNA), according to a new study led ...

NusA and NusG then bind to RNA polymerase during the elongation process to make an RNA copy of the DNA sequence. Finally, the transcription must be terminated at the appropriate spots in the genome.

The newly revealed structure of a key complex involved in copying DNA will lead to a better understanding of the process ...

However, its regulatory mechanism remains insufficiently understood. Researchers have now uncovered the role of mitochondrial transcription elongation factor in maintaining the balance between mtDNA ...

Together with the higher speed of this elongation speed (Pol II speed), the researchers also observed changes in the so-called splicing, a further work step within the transcription process from ...

Mitochondrial transcription elongation factor maintains the balance between transcription and replication of mitochondrial DNA offering insights into potential treatments for mitochondrial disease ...