Papa believes that during the gradual development of type 2 diabetes, the stress of processing large amounts of insulin within the ER compartments of beta cells can stress the ER. Using new techniques ...

The endoplasmic reticulum (ER) is an organelle that has essential roles in multiple cellular processes that are required for cell survival and normal cellular functions.

Inside cells, there exists an extensive system of canals known as the endoplasmic reticulum (ER), which consists of ...

The peripheral endoplasmic reticulum (ER) forms a continuous, dynamic network of tubules that plays an important role in protein transport and quality control, cellular signaling, and stress response.

The ER is the cells main “shipping port” that packages proteins and lipids, checks their quality, and facilitates their transport within the cell. For these vital processes, energy in the form of ATP, ...

The endoplasmic reticulum (ER) is the portion of the cell responsible for manufacturing and folding proteins. Proteins are essential for a wide range of cellular functions—as enzymes ...

Sometimes, however, they are located at the endoplasmic reticulum, a continuous cell-wide membrane network. Although many proteins originate in the cytosol, they subsequently have to be brought to ...

Their findings reveal that by targeting reticulon-4 (RTN4), a key regulator of ER membrane curvature, it is possible to induce pyroptosis in cancer cells and promote antitumor immunity.

The following is a summary of “ER-α36 prevents high glucose-induced cellular senescence and apoptosis in renal tubular cell,” ...

How breast cancer cells lose their ER. Two cellular proteins known as 14-3-3τ and ERα36 have been previously implicated in the development of breast cancer resistance to endocrine therapy.

About one-fourth of recurrent estrogen receptor-positive (ER+) breast cancers lose ER expression, which renders them resistant to endocrine therapy and able to grow uncontrolled. A team of researchers ...