Inside cells, there exists an extensive system of canals known as the endoplasmic reticulum (ER), which consists of ...

The endoplasmic reticulum (ER) is an organelle that has essential roles in multiple cellular processes that are required for cell survival and normal cellular functions.

Scientists at the University of Western Australia and the Perron Institute for Neurological and Translational Science have ...

SLC35B1 transports ATP into the ER, and its structure offers potential for targeted therapies in diseases linked to ER stress. A team of scientists has solved a long-standing question in cell biology ...

The endoplasmic reticulum (ER) is the portion of the cell responsible for manufacturing and folding proteins. Proteins are essential for a wide range of cellular functions—as enzymes ...

The ER is the cells main “shipping port” that packages proteins and lipids, checks their quality, and facilitates their transport within the cell. For these vital processes, energy in the form of ATP, ...

Sometimes, however, they are located at the endoplasmic reticulum, a continuous cell-wide membrane network. Although many proteins originate in the cytosol, they subsequently have to be brought to ...

How breast cancer cells lose their ER. Two cellular proteins known as 14-3-3τ and ERα36 have been previously implicated in the development of breast cancer resistance to endocrine therapy.

Their findings reveal that by targeting reticulon-4 (RTN4), a key regulator of ER membrane curvature, it is possible to induce pyroptosis in cancer cells and promote antitumor immunity.

About one-fourth of recurrent estrogen receptor-positive (ER+) breast cancers lose ER expression, which renders them resistant to endocrine therapy and able to grow uncontrolled. A team of researchers ...