Inside cells, there exists an extensive system of canals known as the endoplasmic reticulum (ER), which consists of membrane-encased tubes that are partially broken down as needed—for instance ...

In biology textbooks, the endoplasmic reticulum is often portrayed as a distinct, compact organelle near the nucleus, and is ...

The proteins that will be secreted by a cell are also directed to the ER during translation, where they end up in the lumen, the internal cavity, where they are then packaged for vesicular release ...

Here I will primarily discuss a key immune cell—the macrophage—and its ... role in pathogenesis through alterations in the endoplasmic reticulum (ER). In addition to engulfing superfluous ...

In biology textbooks, the endoplasmic reticulum is often portrayed as a distinct, compact organelle near the nucleus, and is ...

To overcome the elevated ER stress, an adaptive mechanism known as the unfolded protein response (UPR) is activated in cells. However, persistent ER stress and maladaptive UPR can lead to defects in ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Endoplasmic reticulum (ER) plasticity and ...