But what happens when a mutation occurs over multiple genes? Deletions involve the loss of DNA sequences. Phenotypic effects of deletions depend on the size and location of deleted sequences on ...

Mutations can be caused by high-energy sources ... bases (deletion), the making of two copies for a single base (point duplication) or the addition of a new base or even several bases (insertion).

Background: The mutation is a tandem duplication (a series of adjacent repeats of a DNA sequence) of exon 13 of the gene UBTF, which normally promotes expression of the cell's protein translation ...

This is especially true of the internal tandem duplication (ITD) FLT3 mutation (FLT3-ITD mutation). The FLT3-ITD mutation involves multiple copies of the mutated FLT3 gene existing in a row.

Here, a single mutation has resulted in a new protein ... each can evolve in separate directions. The duplication of genes or even entire genomes is turning out to be ubiquitous.

Genetic analysis revealed a homozygous in-frame duplication of 21 bp in SLC34A1, which encodes the renal sodium–inorganic phosphate cotransporter NaPi-IIa, as the causative mutation. Functional ...

Gene duplication is very important for the evolution ... However, when genes are accidentally duplicated, a beneficial mutation can be created while the original gene continues to function.

Genetic mutations can be of many types, including missense, nonsense, insertion, deletion, duplication, frameshift, and repeat expansion mutations. D614G mutation is a missense mutation wherein an ...

At the same time that duplication rates were heating up, other types of mutation — such as single letters changes in the genetic sequence — slowed down. All the duplication activity resulted ...

Variant and copy number calls are made using a unique bioinformatics pipeline detecting all types of mutations including single nucleotide substitutions, indels, and frameshifts caused by deletion/ ...