"In our previous papers, we showed that methylation of certain CpG dinucleotides was strongly associated with gene activity. We called such dinucleotides CpG traffic lights. Now we have ...

It is abundantly clear that mutations, whether inherited through the germ line or, more commonly, arising in somatic tissues later in life, 1 can cause cancer. These mutations abnormally enhance ...

They also confirmed the mechanism of action—deposition of methylation at CpG dinucleotides—in vitro. After one dose of epieditor repressed PCSK9 in the cell line for six months, the team moved ...

CpG density was computed as the ratio of observed to expected CG dinucleotides in a 3-kb window, as described by Saxonov et al. 36 The 1000 most variable loci among those falling into the top and ...

They noticed in these data that cancer cells with certain genetic aberrations were far and away more likely to have CpG to TpG mutations. These were cells known to be deficient in their ability to ...

"In our previous papers, we showed that methylation of certain CpG dinucleotides was strongly associated with gene activity. We called such dinucleotides CpG traffic lights. Now we have ...