Apoptosis or programmed cell death (PCD) is a genetically programmed ... The genetic basis of a signaling pathway leading to PCD was initially identified in the nematode C. elegans 2.

An understanding of normal cellular function has been gained from research characterizing various signal transduction pathways. Despite these advances, processes responsible for neoplastic ...

Cells use a variety of programmed cell death mechanisms to maintain homeostasis through cellular self-destruction, including apoptosis, necroptosis, and pyroptosis. Elina is a PhD candidate at the ...

Programmed cell death serves as a critical defense mechanism during viral infection. The kinases RIPK1 and RIPK3, central ...

Caenorhabditis elegans drp-1 and fis-2 Regulate Distinct Cell-Death Execution Pathways Downstream of ced-3 and Independent ... release of caspase activators from mitochondria during apoptosis. Here we ...

Apoptosis is an important cellular process that allows cells to die in a programmed fashion, essential for embryo development, homeostasis, and cancer development. This 3D animation provides an ...

Many cancers have developed sophisticated mechanisms to do this by hijacking components of the apoptosis, necrosis, and autophagy signaling pathways. By deactivating these, cancers can avoid cell ...

During chemotherapy, apoptosis can morph into pyroptosis ... it must trigger biological pathways that lead to cell death. The scientists' elegant research, which includes analyses of blood ...

Fos, are integral to the brain's response to stimuli. Initially identified as a proto-oncogene, c-Fos is essential for neural ...

We believe this might be a natural mechanism to keep the beta cell population under ... a higher rate of death by apoptosis. When they blocked the IGFBP3/TMEM219 pathway, beta cells were protected ...

Here’s how it works. At the cellular level, death is essential for life. Apoptosis, sometimes called "cellular suicide," is a normal, programmed process of cellular self-destruction. Even though ...