The growth factor Angiotensin-2 signals through Angiotensin receptor type 1 (AT1-R) in a broad range of cell types and tumours and through the type-2 receptor (AT2-R) in a more restricted group of ...

The group then turned to organoid culture to test the ability of subpopulations ... whereas adding WNT inhibitors promoted the differentiation of AT2 cells into AT1 cells. This result underscores ...

These study findings, published today in Cell Stem Cell, show that the long-held assumption that AT1 and AT2 cells behave the same way in children and in adults is untrue. The lung alveolus is ...

Researchers have now grown lung organoids from human embryonic stem cells (hESCs) that, after implantation in mice, can develop mature alveolar type 1 (AT1) and AT2 cells and architecture ...

with alveolar type 1 (AT1) cells reprograming into alveolar type 2 (AT2) cells (two very different lung alveolar epithelial cells), promoting cell regeneration, rather than AT2 cells differentiating ...

The lining of the alveoli is made of two distinct types of cells -- alveolar type 1 (AT1) and alveolar type 2 (AT2). And while they're similarly named, these two cells couldn't be more different.

"Lung injuries activate AT2 stem cells, which then orchestrate the healing process by producing AT1 cells. As people age, AT2 cells become dysfunctional—instead of repairing the lungs ...

These study findings, published today in Cell Stem Cell, show that the long-held assumption that AT1 and AT2 cells behave the same way in children and in adults is untrue. The lung alveolus is ...

The lining of the alveoli is made of two distinct types of cells — alveolar type 1 (AT1) and alveolar type 2 (AT2). And while they’re similarly named, these two cells couldn’t be more different. AT1 ...