For experimental screening studies in particular, the model assists in understanding the structure of antibodies’ hypervariable regions, how tightly they bind and how well they neutralize antigens.

Their model was able to identify antibody structures that would be the most successful, much more accurately than traditional protein-structure models based on large language models. Then ...

The canonical structure digits for the templates ... as an incorrect alignment will produce a poor-quality structural model of the target antibody, with no possibility of recovery at later stages ...

In the case that you have a single crystal structure, you can omit the –ensemble1 flag. Here we report the time to generate a single, docked model from antibody sequence and antigen crystal ...

Immunotherapies use antibodies—proteins that bind to ... already trained on a vast amount of protein structure data. The model used sequences to predict how proteins fold and interact ...

A recently developed diffusion model for protein structures ... The team also purified the antibody-flu virus protein complex and determined its structure, showing it largely reflected the ...

Debates over AI antibody design terminology have clouded the industry’s shared mission of bringing better therapeutics to the ...

Researchers show that analyzing the 3D shapes of antibodies, not just their genetic sequences, can better group functionally ...

Formolo T et al. (2015), Determination of the NISTmAb Primary Structure, in: State-of-the-Art and Emerging Technologies for Therapeutic Monoclonal Antibody Characterization Volume 2 ...

Although their role is universal, antibody structure varies in different animals. In a new study, researchers have analyzed the antibody Immunoglobulin M in rainbow trout to shed some light on why ...