(A) The structure of a monoclonal antibody, such as infliximab, adalimumab or golimumab, and (B) the structure of certolizumab. Fab: Antibody-binding fragment of immunoglobulin; Fc: Constant fragment.

In little more than five years, German biotechnology company YUMAB (a phonetic play on HUMAB (human monoclonal antibody) in which the “Y” symbolizes the antibody structure) has become a global ...

Here, we discuss strategies to select the best therapeutic antigen targets, to optimize the structure of IgG antibodies and to design related or new structures with additional functions.

Winter founded Cambridge Antibody Technology in 1989, which first discovered adalimumab using phage display technology as part of a development partnership with BASF Pharma. After Abbott bought ...