Platelets are the smallest of the human blood cells, measuring about one-tenth the diameter of a white blood cell. They usually circulate freely, maintained in a mobile but inactive state by ...

Clopidogrel has pharmacological limitations that have prompted the search for more effective ADP-receptor antagonists. Promising results have been achieved with the thienopyridine, prasugrel ...

These mediators function through the activation of G-protein–coupled or ligand-gated ion-channel receptors. Adenosine is derived from ATP and ADP through the actions of enzymes on cellular ...

Intravenous cangrelor, a rapid-acting, reversible adenosine diphosphate (ADP) receptor antagonist, might reduce ischemic events during percutaneous coronary intervention (PCI). In this double ...

The agent, elinogrel (Portola Pharmaceuticals), is a P2Y12 ADP-receptor antagonist similar to clopidogrel, but it is the first agent in this class to be developed in both intravenous and oral ...

Researchers know that two drugs—clopidogrel and ticlopidine—that are used to reduce the risk of heart attack and stroke work by blocking an ADP receptor found on the surface of platelets.

Disrupting ADP binding to its receptor reduced the severity of diarrhea in a mouse model of the disease, suggesting that targeting the P2Y1 may be an effective strategy to control viral diarrhea ...

This study showed that "opioid treatments can reduce the antiplatelet effect of ADP-receptor antagonists," he said. Large clinical trials are needed to confirm this and see how this effect on ...

suggesting that ATP1A1 may participate in ADP-receptor mediated platelet activation.” Based in the lab of Wei Li, M.D., Ph.D., Oliver Li and his co-authors presented the research last month at ...