Sanford is a city in York County, Maine, United States. The population was 21,982 in the 2020 census, making it the seventh largest municipalit…Sanford is a city in York County, Maine, United States. The population was 21,982 in the 2020 census, making it the seventh largest municipality in the state. Situated on the Mousam River, Sanford includes the village of Springvale. The city features many lakes in wooded areas which attract campers.
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