Santa Fe is a district of Veraguas Province in Panama. The population according to the 2000 census was 12,890; the latest official estimate …Santa Fe is a district of Veraguas Province in Panama. The population according to the 2000 census was 12,890; the latest official estimate is 17,341. The district, which lies in the north of the province and comprises its entire Caribbean coastal area, covers a total area of 1,920 km². The capital lies at the town of Santa Fe.