Cape Girardeau is a city in Cape Girardeau and Scott Counties in the U.S. state of Missouri. At the 2020 census, the population was 39,540, making it the 17th-largest in the state. The city is one of two principal cities of the Cape Girardeau, MO-IL Metropolitan Statistical Area, which encompasses Cape Giradeau and Bollinger Counties in Missouri and Alexander County in Illinois, and has a population of 97,517. The sliver of the city located in Scott County is part of the Sikeston Micropolitan Statistical Area, and the entire city forms the core of the Cape Girardeau-Sikeston Combined Statistical Area.
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