Danville is an independent city in the Commonwealth of Virginia in the United States. The city is located in the Southside Virginia region an…Danville is an independent city in the Commonwealth of Virginia in the United States. The city is located in the Southside Virginia region and on the fall line of the Dan River. It was a center of tobacco production and was an area of Confederate activity during the American Civil War, due to its strategic location on the Richmond and Danville Railroad. In April 1865 it briefly served as the third and final capital of the Confederacy before its surrender later that year.